Run as Basic User
RUNAS /trustlevel:"0x20000" "x"
RUNAS /trustlevel:"0x20000" "C:\Users\Espionage724\Downloads\OpenTabletDriver-0.6.5.1_win-x64\OpenTabletDriver.UX.Wpf.exe"
RUNAS /showtrustlevels
Disable Windows Defender
reg add "HKLM\SOFTWARE\Policies\Microsoft\Windows Defender" /v "DisableAntiSpyware" /t "REG_DWORD" /d "1" /f
Disable Startup Delay
reg add "HKCU\Software\Microsoft\Windows\CurrentVersion\Explorer\Serialize" /v "StartupDelayInMSec" /t "REG_DWORD" /d "0" /f
Disable SmartScreen
General
Windows Store Apps
Microsoft Edge
reg add "HKLM\SOFTWARE\Microsoft\Windows\CurrentVersion\Explorer" /v "SmartScreenEnabled" /t "REG_SZ" /d "Off" /f
reg add "HKCU\SOFTWARE\Microsoft\Windows\CurrentVersion\AppHost" /v "EnableWebContentEvaluation" /t "REG_DWORD" /d "0" /f
reg add "HKLM\SOFTWARE\Policies\Microsoft\MicrosoftEdge\PhishingFilter" /v "EnabledV9" /t "REG_DWORD" /d "0" /f
Remove Most Modern UI Apps
Not necessary with Local Account log-ins and Pro/Enterprise/LTSC editions
Tested fine on 20H2, 21H2, and 23H2

This broke the start menu on 1809

2024/08: May cause Explorer windows to act broken at times on 11 23H2
Get-AppxPackage -allusers | Remove-AppxPackage
Remove OneDrive
taskkill /IM "OneDrive.exe" /F
%windir%\SysWOW64\OneDriveSetup.exe /uninstall
rmdir "%UserProfile%\OneDrive" "%ProgramData%\Microsoft OneDrive" "%LocalAppData%\Microsoft\OneDrive" "C:\OneDriveTemp" /S /Q
reg delete "HKCR\CLSID\{018D5C66-4533-4307-9B53-224DE2ED1FE6}" /f
reg delete "HKCR\Wow6432Node\CLSID\{018D5C66-4533-4307-9B53-224DE2ED1FE6}" /f
Remove Defender

Requires Enterprise/Server
Uninstall-WindowsFeature -Name Windows-Defender
GPU Shader Cache Wipe
Intel
DEL /F /Q "%UserProfile%\AppData\LocalLow\Intel\ShaderCache\"*
MEM_TOP_DOWN
REG ADD "HKEY_LOCAL_MACHINE\SYSTEM\CurrentControlSet\Control\Session Manager\Memory Management" /v "AllocationPreference" /t "REG_DWORD" /d "0x100000" /f
Etc
REG ADD "HKEY_LOCAL_MACHINE\SYSTEM\CurrentControlSet\Control\Session Manager\Memory Management" /v "DisablePagingExecutive" /t "REG_DWORD" /d "1" /f
REG ADD "HKEY_LOCAL_MACHINE\SYSTEM\CurrentControlSet\Control\Session Manager\Memory Management" /v "LargeSystemCache" /t "REG_DWORD" /d "1" /f
REG ADD "HKEY_LOCAL_MACHINE\SYSTEM\CurrentControlSet\Control\Session Manager\Memory Management" /v "SystemPages" /t "REG_DWORD" /d "0XFFFFFFFF" /f
ICMP Echo Allow
"netsh.exe" advfirewall firewall set rule name="Core Networking Diagnostics - ICMP Echo Request (ICMPv4-In)" profile="private,public" new enable="yes" && "netsh.exe" advfirewall firewall set rule name="Core Networking Diagnostics - ICMP Echo Request (ICMPv4-Out)" profile="private,public" new enable="yes" && "netsh.exe" advfirewall firewall set rule name="Core Networking Diagnostics - ICMP Echo Request (ICMPv6-In)" profile="private,public" new enable="yes" && "netsh.exe" advfirewall firewall set rule name="Core Networking Diagnostics - ICMP Echo Request (ICMPv6-Out)" profile="private,public" new enable="yes"
Disable
"netsh.exe" advfirewall firewall set rule name="Core Networking Diagnostics - ICMP Echo Request (ICMPv4-In)" profile="private,public" new enable="no" && "netsh.exe" advfirewall firewall set rule name="Core Networking Diagnostics - ICMP Echo Request (ICMPv4-Out)" profile="private,public" new enable="no" && "netsh.exe" advfirewall firewall set rule name="Core Networking Diagnostics - ICMP Echo Request (ICMPv6-In)" profile="private,public" new enable="no" && "netsh.exe" advfirewall firewall set rule name="Core Networking Diagnostics - ICMP Echo Request (ICMPv6-Out)" profile="private,public" new enable="no"